MicroRNA Function in Cartilage
Masato SATO, M.D., Ph.D.
Department of Orthopaedic Surgery, Surgical Science,
Tokai University school of Medicine
MicroRNAs (miRNAs) are single-stranded noncoding RNAs of ~22 base pairs that regulate gene expression by repressing translation. We found that some miRNAs are involved in the senescence of chondrocytes, and the juvenile properties of chondrocytes. In my presentation, initially, I will talk about background information on miRNAs and cartilage. Then, I will introduce our clinical study on the use of cell sheets for cartilage regeneration therapy. And finally, I will return to discuss on the potency of miRNAs. We hope that miRNAs could be markers of the characteristics of cell sheets and also potential biomarkers for cartilage regeneration therapy.